Metamizole Sodium

Description

What is Metamizole Sodium?

Metamizole sodium, a nonsteroidal mitigating drug, has been generally utilized over the most recent 100 years. Its adequacy as a pain relieving and antipyretic is irrefutable. Just couple of instances of intense kidney injury (AKI) actuated by metamizole sodium monohydrate were accounted for in the clinical writing. We report 11 grown-up patients with AKI that came about because of metamizole sodium ingestion.

The information propose a decent guess in these instances of AKI. Renal biopsies, corticosteroids treatment, or renal substitution treatment appear to be excessive. Hydration was adequate to guarantee unconstrained recuperation.

Metamizole Sodium Basic information

Product Name:	Metamizole sodium
Synonyms:	(antipyrinylmethylamino)methanesulfonicacidsodiumsalt;(antipyrinylmethylamino)-methanesulfonicacimonosodiumsalt;(antipyrinylmethylamino)-methanesulfonicacisodiumsalt;algopyrine;aminopyrinesodiumsulfonate;antipyrine,4-(methylamino)-,monomethosulfate,sodiumsalt;barone;bonpyrin
CAS:	68-89-3
MF:	C13H16N3NaO4S
MW:	333.34
EINECS:	200-694-7
Product Categories:	Aromatics; Heterocycles; DIO – DIZForensic and Veterinary Standards; Cosmetic Ingredients & Chemicals; Intermediates & Fine Chemicals; Sulfur & Selenium Compounds; PHARMACEUTICALS; Alphabetic; Drugs&Metabolites; Neat Compounds
Mol File:	68-89-3.mol

Algopyrine Chemical Structure

Metamizole sodium

Barone Chemical Properties

Melting point	227 °C
density	1.388 g/cm3
storage temp.	2-8°C
color	Minute crystals
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	68-89-3(CAS DataBase Reference)
NIST Chemistry Reference	Dipyrone(68-89-3)
EPA Substance Registry System	Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-, sodium salt (1:1) (68-89-3)

Bonpyrin Drug Instruction

Alias: dipyrone, NOVALGIN; Noramidopyrine, Metamizole sodium,metamizole
Property: This product is white or yellow-white crystal or crystalline powder, odorless, slightly bitter taste, soluble in water.
Action: Dipyrone is the derivative of aminopyrine, its has a significant effect of antipyretic analgesia. The antipyretic effect of it is three times as aminopyrine, the analgesic effect is similar to that of aminopyrine.
Process vivo: Easily absorbed orally, mainly metabolized by the liver and excreted of renal
Indications: It is mainly used for cooling, acute arthritis, headache, rheumatic neuralgia, toothache and muscle pain etc.

Dosage
Oral or intranasal administration. For oral, the adult should take 0.5g of the medicine and three times a day, the amount of the child is 8-10mg/ kg, the number of the times is according to the necessary. For intranasal, the child under 5 years old can take 1-2drops for each nostril, can take the medicine another time if necessary,for the patient above 5 years old increase the dosage appropriately.

Note
1, The dosage should be controled strictly to prevent collapse.
2, The intramuscular injection can cause atrophy and erosion to the local muscle, it is abandoned now.
3, The patient who has a allergy to the praziquantel can not use the dipyrone
4, It not suitable for a long-term application, Please pay attention to the granulocytes.

Metamizole Sodium Uses

Uses	A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
	Metamizole Sodium (noramidopyrine-methane-sulfonate, dipyron) is a nonsteroidal calming drug (NSAID), with pain relieving, antipyretic, spasmolytic, and feeble mitigating properties. In view of its substance structure it has a place with the gathering of pyrazolones, alongside phenazone, aminophenazone, propyphenazone, nifenazone (1, 2). Metamizole sodium monohydrate impact is exceptional among NSAIDs. Signs for its utilization are postoperative torment, intense injury, disease and colic agony, and headache.
	Methamizole sodium has expressed analgesic and fever-reducing properties and poorly expressed anti-inflammatory action, and is very convenient in cases where high concentrations of drug need to be quickly reached. Methamizole sodium is used for relieving pain of various origins (renal and biliary colic, neuralgia, myalgia, trauma, burns, headaches, and toothaches). Use of this drug may cause allergic reactions, and long-term use may cause granulocytopenia.