β sitosterol

Description

What is β sitosterol

β sitosterol is one of a few plant-based substances known as phytosterols. It is comparable in substance design to the cholesterol your body makes.

Normally found in plants, β sitosterol can be devoured through food sources like vegetable oils, nuts, seeds, and vegetables. It is likewise accessible in supplement structure, as well as a lipid emulsion.

Beta-sitosterol is now and again used to decrease elevated cholesterol. It has likewise been read up for a large group of other medical issue. This article will survey its possible purposes, incidental effects, measurements, and that’s just the beginning.

β sitosterol Basic information

Product Name:	Beat-Sitosterol	EINECS:	83-46-5
CAS:	64997-52-0	Extract Solvent:	Water&Ethanol

ANALYSIS	SPECIFICATION
Appearance	A White or almost white, crystalline Powder, Practically insoluble in water, soluble in tetrahydrofuran, sparingly soluble in ethyl acetate.
Identification 1. Color reaction 2. Retention time	Positive The tetention time of the major peak conforms to that of the standard preparation
Specific optical rotation	-15-28°
Assay	β-Sitosterol≥80%
	Total Sterols≥95%
Loss on drying	≤2.5%
Total Ash	≤0.5%
Heavy metals	≤10ppm
Arsenic	≤5ppm
Total Plate Count	≤3000cfu/g
Yeast & Mold	≤100cfu/g
E.Coli	Negative
Salmonella	Negative

β sitosterol Benefits:

We treated β sitosterol on 2,4-dinitrofluorobenzene (DNFB)-induced AD-like skin lesions in NC/Nga mice, anti-CD3/anti-CD28-stimulated splenocytes, and phorbol myristate acetate/calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells.

Histological analysis, ELISA, PCR, caspase-1 assay, and Western blot analysis were performed. Beta-sitosterol reduced the total clinical severity in DNFB-treated NC/Nga mice. Infiltration of inflammatory cells and number of scratching were clearly reduced in the β sitosterol-treated group compared with the DNFB-treated group. BS significantly reduced the levels of inflammation-related mRNA and protein in the AD skin lesions.

Beta sitosterol for sale significantly reduced the levels of histamine, IgE, and interleukin-4 in the serum of DNFB-treated NC/Nga mice. The activation of mast cell-derived caspase-1 was decreased by treatment with BS in the AD skin lesions. BS also significantly decreased the production of tumor necrosis factor-α from the stimulated splenocytes.

In the stimulated human mast cell line, HMC-1 cells, increased intracellular calcium levels were decreased by treatment with beta-sitosterol. Further, BS inhibited the production and mRNA expression of TSLP through blocking of caspase-1 and nuclear factor-κB signal pathways in the stimulated HMC-1 cells. These results provide additional evidence that beta-sitosterol may be considered an effective therapeutic drug for the treatment of AD.

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