Zileuton

Description

What is Zileuton?

Zileuton is a member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. It has a role as an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, a non-steroidal anti-inflammatory drug, an anti-asthmatic drug, a leukotriene antagonist and a ferroptosis inhibitor. It is a member of ureas and a member of 1-benzothiophenes. It derives from a hydride of a 1-benzothiophene. (Source: ChEBI)

Introduction

Product Name:	Zileuton
Synonyms:	Leutrol; Zileutonum; Ziluton
CAS:	111406-87-2
MF:	C11H12N2O2S
MW:	236.29
EINECS:	601-087-3
Product Categories:	Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Active Pharmaceutical Ingredients; Respiratory Drugs

Chemical Structure

Zileuton

Chemical Properties

Melting point	157-158°C
Boiling point	449.4±47.0 °C(Predicted)
density	1.401±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min)
pka	pKa 10.3(H2O t undefined I undefined) (Uncertain)
form	powder
color	white to off-white

Zileuton Uses And Synthesis

Zileuton, a benzothiophene N-hydroxyurea, is the only approved inhibitor of 5-lipoxygenase. It is believed to intervene with allergic and inflammatory diseases by suppression of leukotriene (LT) biosynthesis. The compound belongs to the class of iron ligand-type inhibitors of 5-lipoxygenase that not only chelates the active site iron of the enzyme but also possesses weak-reducing properties.

Maxmedchem, a global supplier of Zileuton, 111406-87-2 offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer other intermediates with supportive technical package required for evaluation.

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