Tudca

Description

What is Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxycholic acid, on the other hand, is produced abundantly in bears and has been used for centuries as a natural remedy in some Asian countries.

It is approved in Italy and Turkey for the treatment of cholesterol gallstones and is an investigational drug in China, Unites States, and Italy. Tauroursodeoxycholic acid is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. The only completed clinical trial thus far is a phase III clinical trial comparing tauroursodeoxycholic acid and ursofalk in PBC adult patients, but as of June 2013 no results of this trial have been published.(Source: DrugBank)

Basic information

Product Name:	TAUROURSODEOXYCHOLIC ACID
Synonyms:	Tauroursodeoxycholate; Taurursodiol; Taurolite;
CAS:	14605-22-2
MF:	C26H45NO6S
MW:	499.7
EINECS:	1308068-626-2
Product Categories:	Chiral Reagents; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Herb extract

Chemical Structure

tudca

Chemical Properties

Melting point	173-175°C
density	1.216±0.06 g/cm3(Predicted)
refractive index	46 ° (C=1, EtOH)
storage temp.	+15C to +30C
pka	1.42±0.50(Predicted)
InChIKey	BHTRKEVKTKCXOH-LBSADWJPSA-N

Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways

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Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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