Society and culture of Ibuprofen

Availability

Ibuprofen became available by prescription in the UK in 1969 and in the US in 1974.Since then, it has been available over the counter in pharmacies supermarkets, and other stores around the world because it was well tolerated and because it was tested in populations and in Phase IV trials (post-approval studies) has rich experience.Ibuprofen is an International Nonproprietary Name (INN), British Approved Name (BAN), Australian Approved Name (AAN) and United States Adopted Name (USAN).In the United States it has been sold under the brand names Motrin and Advil from 1974 and 1984 respectively. Ibuprofen is common in the United States up to the FDA’s 1984 OTC dose limit, with higher doses rarely prescribed.In 2009, the first ibuprofen injection was approved in the United States under the brand name Caldolor.

Route 

Ibuprofen is available orally (tablet, capsule, or suspension) and intravenously.

Research

Ibuprofen is sometimes used to treat acne because of its anti-inflammatory properties and is sold in topical form in Japan for the treatment of adult acne.Like other NSAIDs, ibuprofen can be used to treat severe orthostatic hypotension (low blood pressure while standing).The role of NSAIDs in the prevention and treatment of Alzheimer’s disease is unclear.Ibuprofen is associated with a lower risk of Parkinson’s disease and may delay or prevent it. Aspirin, other NSAIDs, and paracetamol (acetaminophen) had no effect on Parkinson’s risk.In March 2011, researchers at Harvard Medical School announced in Neurology that ibuprofen is neuroprotective and reduces the risk of Parkinson’s disease.A 38% reduced risk of Parkinson’s disease was reported in people who regularly took ibuprofen, but no such effect was found for other pain relievers such as aspirin and paracetamol.Given the possible adverse effects on the urinary and digestive systems, the use of ibuprofen to reduce the risk of Parkinson’s disease in the general population is not without problems.Certain dietary supplements may be dangerous when taken with ibuprofen and other NSAIDs, but as of 2016, more research is needed to know for sure. These supplements include those that prevent platelet aggregation and include ginkgo, garlic, ginger, lingonberry, angelica, feverfew, ginseng, turmeric, spiraea (Filipendula ulmaria), and willow (Salix spp.); Vegetarian foods, including chamomile, horse chestnut, fenugreek, and red clover; and those that increase bleeding risk, such as tamarind.