Rosiglitazone Maleate

Description

Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

Rosiglitazone Maleate activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.

Rosiglitazone maleate Basic information

Product Name:	Rosiglitazone maleate
Synonyms:	ROSIGLITAZONE MALEATE; Rosiglitazone Tartrate;
CAS:	155141-29-0
MF:	C22H23N3O7S
MW:	473.5
EINECS:	642-163-6
Product Categories:	API; Inhibitor; Antidiabetic; Intermediates & Fine Chemicals; Pharmaceuticals; API’s; Active Pharmaceutical Ingredients

Rosiglitazone maleate Chemical Structure

Rosiglitazone maleate

Avandia Chemical Properties

Melting point	235-240°C
storage temp.	-20°C Freezer
pka	6.1; 6.8(at 25℃)
form	White powder
InChIKey	HCDYSWMAMRPMST-NTCAYCPXSA-N

Avandamet Usage And Synthesis

Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues.

Chemical Properties

White To Off-White Solid

Uses

Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).

Thiazole alkanes antidiabetic drug

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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