PARECOXIB SODIUM

Description

Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Product Name:	PARECOXIB SODIUM
Synonyms:	sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide; sodium salt; parecoxib sodium salt; Dynastat;
CAS:	198470-85-8
MF:	C19H17N2NaO4S
MW:	392.40405
EINECS:	813-689-5
Product Categories:	Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File:	198470-85-8.mol

Parecoxib Sodium Chemical Formula

Parecoxib Sodium Salt Chemical Properties

Melting point:	273-275°C
storage temp.	Refrigerator

PARECOXIB SODIUM Usage And Synthesis

Chemical Properties:	White Solid
Uses	Anti-inflammatory, analgesic.

DYNASTAT Pfizer Functions

Parecoxib Sodium is indicated for relief of the signs and symptoms of osteoarthritis.
For relief of the signs and symptoms of rheumatoid arthritis in adults.
For relief of the signs and symptoms of particular or poly articular course Juvenile Rheumatoid Arthritis (JRA) in patients.
For the management of acute pain in adults.
For the treatment of primary dysmenorrhea.
For the acute treatment of migrain attacks with or without aura in adults.
The safety and effectiveness of Parecoxib have not been established for cluster headache, which is present in an older, predominantly male, population.