Nimesulide

Description

What is Nimesulide?

Nimesulide is a nonsteroidal antiinflammatory drug (NSAID) with relative specificity for COX-2 that is not available in the United States, but is used widely in other countries in the treatment of acute pain. Nimesulide has been linked to a low rate of transient serum enzyme elevations during therapy, but also to many instances of clinically apparent acute liver injury that can be severe and can result in acute liver failure, need for emergency liver transplantation and death.

Product Name:	Nimesulide
Synonyms:	nimed;4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE;CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD);CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD);CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD);4-Nitro-2-phenoxymethanesulfonamide;Nide;Nidol
CAS:	51803-78-2
MF:	C13H12N2O5S
MW:	308.31
EINECS:	257-431-4
Product Categories:	All Inhibitors;Inhibitors;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Isotope Labelled Compounds;Sulfur & Selenium Compounds;Other APIs
Mol File:	51803-78-2.mol

Nimesulide Chemical Structure

Nimesulide Structure

Nimed Chemical Properties

Melting point	140-146°C
Boiling point	442.0±55.0 °C(Predicted)
density	1.451±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
pka	pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
form	neat
Water Solubility	Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax	391nm(H2O)(lit.)
Merck	14,6548
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference	51803-78-2(CAS DataBase Reference)
EPA Substance Registry System	Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

Nimesulide Benefits

Nimesulide 100mg Tablet is utilized to treat a throbbing painfulness. It blocks synthetic couriers in the cerebrum that let us know we have torment. It is successful in alleviating torment brought about by migraine, headache, nerve torment, toothache, sore throat, period (feminine) agonies, joint pain, and muscle hurts. This medication is broadly utilized and seldom causes secondary effects whenever taken at the right dose.

Accept it as getting the most benefit is recommended. Try not to take more or longer than required as that can be perilous. As a rule, you ought to take the least portion that works, for the most limited conceivable time.

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