Nefopam Hydrochloride

Description

What is nefopam hydrochloride?

Nefopam hydrochloride is a pain reliever. It treats moderate torment, for instance after an activity or a serious physical issue, dental agony, joint torment and muscle agony, or torment from disease.

You can likewise take nefopam hydrochloride for different sorts of long haul torment when more vulnerable pain relievers never again work.

Nefopam hydrochloride is normally recommended when different pain relievers, for example, paracetamol or naproxen don’t assist your pain.Your with tormenting ought to begin to work on 1 to 2 hours in the wake of taking the tablets.The most normal aftereffects incorporate inclination wiped out or tipsy.

Nefopam hydrochloride high could variety your pee pink, yet this is innocuous.

Nefopam Hydrochloride Basic information

Product Name:	Nefopam hydrochloride
Synonyms:	BENZOXAZOCINE HYDROCHLORIDE; LABOTEST-BB LT00159839; 3,4,5,6-TETRAHYDRO-5-METHYL-1H-2,5-BENZOXAZOCINE HYDROCHLORIDE; 3,4,5,6-TETRAHYDRO-5-METHYL-1-PHENYL-1H-2,5-BENZOXAZOCINE HYDROCHLORIDE; NEFOPAM HCL;NEFOPAM HYDROCHLORIDE; 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride; NAFOPAN HCL
CAS:	23327-57-3
MF:	C17H20ClNO
MW:	289.8
EINECS:	245-585-5
Product Categories:	raw material; Other APIs; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; API
Mol File:	23327-57-3.mol

Nefopam Hcl Chemical Structure

Nefopam hydrochloride

Acupan Chemical Properties

Melting point	238-242°
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL, clear
form	powder
color	white to beige
CAS DataBase Reference	23327-57-3(CAS DataBase Reference)

Nefopam Hydrochloride Tablets Usage And Synthesis

Chemical Properties	White to Off-White Solid
Uses	A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Manufacturing Process	The starting material is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol) of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml tetrahydrofuran and then slowly added in small portions to a solution of 5.5 grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with cooling and stirring. The mixture is then refluxed for 18 hours, cooled and then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium hydroxide and 16 ml water. After removal of precipitated salts by filtration, the solution remaining is concentrated under reduced pressure and the residue dried to yield 19.5 grams of crude product. Yield after conversion to the hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to 133°C. 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until all the benzene is distilled off. The residual oil is heated to 105°C and held at this temperature for 1 hour, then cooled and dissolved in 30 ml water. This aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide, extracted with ether, and the extracts washed with water, dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP 238° to 242°C. Nefopam hydrochloride is a NSAID that is utilized for transient administration of agony. Nefopam hydrochloride high tracks down application in help with discomfort previously or post-medical procedure. It is additionally utilized briefly to treat serious joint and muscle torment in illnesses like osteoarthritis and rheumatoid joint inflammation. Nefopam hydrochloride nhs blocks torment signals, so the cerebrum doesn’t see the seriousness of agony. Hence, nefopam hydrochloride frees the body from the impression of agony.
Therapeutic Function	Muscle relaxant, Antidepressant