Natamycin

Description

What is Natamycin?

Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect. (Source: NCI Thesaurus (NCIt))

Basic information

Product Name:	Natamycin
Synonyms:	PIMAFUCIN; PIMARICIN; PIMARICIN, STREPTOMYCES CHATTANOOGENSIS; Natacyn;
CAS:	7681-93-8
MF:	C33H47NO13
MW:	665.73
EINECS:	231-683-5
Product Categories:	Food & Feed ADDITIVES; Intermediates & Fine Chemicals; Pharmaceuticals; antibiotic; APIs

Chemical Structure

Natamycin

Chemical Properties

Melting point	2000C (dec)
alpha	D20 +278° (c = 1 in CH3COOH)
Boiling point	952℃
density	1.0 g/mL at 20 °C(lit.)
refractive index	1.5960 (estimate)
Fp	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in DMSO
form	aqueous suspension
pka	pKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain)
Water Solubility	0.41g/L(21 ºC)
Sensitive	Light Sensitive
Merck	13,6453
BRN	1614878
Stability:	Light sensitive

Usage And Synthesis

Natamycin is used to treat fungal infections, including Candida, Aspergillus, Fusarium, etc. It is also used as eye drops or oral medicine. In these applications, the human body absorbs less Natamycin. When taken orally, it is basically not absorbed from the gastrointestinal tract, which makes it unsuitable as a systemic infectious drug. Natamycin is also used in eye drops. Its 5% natamycin content is suitable for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by microorganisms, including Fusarium solani keratitis.

Chemical Properties	White to Off-White Solid
Originator	Pimafucine,Beytout,France,1964
Uses	Natamycin (l), from Streptomyces nataIensis and Streptomyces chat tanoogensis, is used for the control of diseases of bulbs.
	Polyene antifungal antibiotic
	analgesic, antimigraine

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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