Minocycline Hydrochloride

Description

Minocycline Hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline Hydrochloride binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria.

In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline’s neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes. (Source: NCI Thesaurus

Minocycline hydrochloride Basic information

Product Name:	Minocycline hydrochloride
Synonyms:	KlinoMycin, Minocycline chloride, MinoMycin, NSC 141993; Minocycline hydrochloride Solution, 100ppm; Minocycline hydrochloride, >=98%;
CAS:	13614-98-7
MF:	C23H28ClN3O7
MW:	493.94
EINECS:	237-099-7
Product Categories:	DAYPRO; antibiotic; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; API; Antibacterial; Peptide Synthesis/Antibiotics
Mol File:	13614-98-7.mol

Minocycline hydrochloride Chemical Structure

Minocycline hcl Chemical Properties

Melting point	205-210° (dec)
Boiling point	813℃
Fp	>110°(230°F)
storage temp.	2-8°C
solubility	Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
form	crystalline
color	yellow
Water Solubility	Freely soluble in water
Merck	14,6202
Stability:	Light Sensitive
InChIKey	GLMUAFMGXXHGLU-VQAITOIOSA-N
CAS DataBase Reference	13614-98-7(CAS DataBase Reference)

Minomycin Usage And Synthesis

Chemical Properties	Yellow Crystalline Powder
Uses	Second generation tetracycline antibiotic. Antibacterial.
	antiinflammatory
	Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Therapeutic Function	Antibiotic
Veterinary Drugs and Treatments	Minocycline may be useful for treating Brucellosis (in combination with aminoglycosides), Lyme disease, and certain nosocomial infections where other more commonly used drugs are ineffective. It has been investigated as adjunctive therapy for treating hemangiosarcomas, but early results have been disappointing.