Menadione

Description

What is Menadione?

Menadione is an essential fat soluble vitamin that is important in maintaining normal coagulation, serving as a cofactor in the activation of several clotting factors and anticoagulant proteins. There is no evidence that vitamin K supplementation, in physiologic or even higher doses, causes serum enzyme elevations, liver injury or jaundice.

Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as a nutraceutical, a human urinary metabolite, an angiogenesis inhibitor, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an antineoplastic agent. It is a member of 1,4-naphthoquinones and a vitamin K.

Basic information

Product Name:	Menadione
Synonyms:	VITAMIN K3; Vitamin K₃;menadione k3; MENADIONE POWDER USP; menadione vitamin k; menadione sodium bisulphate; menadione sodium bisulfite
CAS:	58-27-5
MF:	C11H8O2
MW:	172.18
EINECS:	200-372-6
Product Categories:	Biochemistry;Vitamins;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals

Chemical Structure

Menadione

Chemical Properties

Melting point	105-107 °C(lit.)
Boiling point	262.49°C (rough estimate)
density	1.1153 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	room temp
solubility	oil: soluble
form	crystalline
color	yellow
Odor	Slight odor
Water Solubility	INSOLUBLE
Sensitive	Light Sensitive
Merck	14,5831
BRN	1908453
Stability:	Stable. May be light sensitive. Incompatible with strong oxidizing agents.
InChIKey	MJVAVZPDRWSRRC-UHFFFAOYSA-N

Menadione Uses And Synthesis

What is menadione used for?

The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K.

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