Lipoic Acid

Description

What is Lipoic acid?

A vitamin of the vitaminB complex. It is one of thecoenzymes involved in the decarboxylationof pyruvate by the enzymepyruvate dehydrogenase. Goodsources of lipoic acid include liverand yeast.

(R)-lipoic acid is the (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. It has a role as a prosthetic group, a nutraceutical and a cofactor. It is a lipoic acid, a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It derives from an octanoic acid and it is a conjugate acid of a (R)-lipoate & an enantiomer of a (S)-lipoic acid.

Basic information

Product Name:	Lipoic acid
Synonyms:	(R)-LIPOIC ACID; thioderm; lipoec; tiobec; acido lipoico
CAS:	62-46-4
MF:	C8H14O2S2
MW:	206.33
EINECS:	200-534-6
Product Categories:	Phytochemical; standardized herbal extract;PHARMACEUTICALS;FINE Chemical & INTERMEDIATES;API;Pharma intermediates

Chemical Structure

Lipoic acid

Chemical Properties

Melting point	48-52 °C(lit.)
Boiling point	315.2°C (rough estimate)
density	1.2888 (rough estimate)
refractive index	1.5200 (estimate)
Fp	>230 °F
solubility	Very slightly soluble in water, very soluble in dimethylformamide, freely soluble in methanol.

Usage And Synthesis

Chemical Properties	Thioctic acid, 6,8-dithiooctanoic acid
Uses	hydrogen-transferring cofactor, potentiating anti-oxidant

The main functions of lipoic acid

One of the main uses of lipoic acid is to treat nerve damage, including neurological diseases in diabetic patients. This dangerous long-term complication can cause pain and loss of consciousness. The disease is due to the high content of sugar (glucose) in the blood, which causes damage to nerve cells by free radicals. Lipoic acid can play a role in inhibiting nerve damage through its antioxidant effect. In addition, it can help diabetics respond to insulin, a hormone that regulates glucose.

Animal experiments have also shown that lipoic acid can increase blood flow to nerves and improve the conduction of nerve impulses. Lipoic acid is also beneficial to the liver, protecting him from free radical damage and helping it to remove toxins from the body.

Additional effect

Lipoic acid may have other potential uses, but more research is needed. Some eye-catching animal experiments have shown that it can prevent the formation of cataracts. Other animal experiments have shown that it can enhance memory (for example, it may help treat Alzheimer’s disease) and protect brain cells from damage caused by insufficient blood supply to the brain.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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