L Tetrahydropalmatine

  • Chemical Name: TETRAHYDROPALMATINE HYDROCHLORIDE
  • CAS No.: 6024-85-7
  • MF: C21H26ClNO4
  • MW:391.89
  • Specification: USP|EP|BP
  • Purity:98% or as customer requested
  • Chemical Properties:White Powder
  • CategorAies: API; Pharmaceuticals
  • Test method: HPLC
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Description

What is L Tetrahydropalmatine?

L tetrahydropalmatine is a berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine. It has a role as an adrenergic agent, a non-narcotic analgesic and a dopaminergic antagonist. It is a berberine alkaloid and an organic heterotetracyclic compound. It derives from a palmatine.

L-tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).

TETRAHYDROPALMATINE HYDROCHLORIDE Basic Information

           

Product Name: TETRAHYDROPALMATINE HYDROCHLORIDE
Synonyms: (D,L)-TETRAHYDROPALMATINE HYDROCHLORIDE; TETRAHYDROPALMATINE HYDROCHLORIDE; SALOR-INT L202088-1EA; 2,3,9,10-tetramethoxy-,hydrochloride,(+-)-berbin; Tetrahydropalmatine Sulfate 6024-85-7; tetrahydro-,hydrochloride,(+-)-palmatin; Tetrahydropalmatine, HCl; corydalis B
CAS: 6024-85-7
MF: C21H26ClNO4
MW: 391.89
Product Categories: Natural Plant Extract; Inhibitors
Mol File: 6024-85-7.mol

Tetrahydropalmatine HCl Chemical Structure

TETRAHYDROPALMATINE HYDROCHLORIDE            

Corydalis B Chemical Properties

Melting point  222-223 °C (decomp)
CAS DataBase Reference 6024-85-7(CAS DataBase Reference)

L Tetrahydropalmatine Benefits:

Brain

L-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats, thereby indicating powerful anti-addiction properties.

Four weeks of l tetrahydropalmatine treatment significantly ameliorated the severity of PAWS—specifically, somatic syndrome, mood states, insomnia, and drug craving, in comparison to a placebo group, in terms of drug addiction.

L-Tetrahydropalmatine reduces the development of anxiety and depression-related symptoms induced by single prolonged stress .

L tetrahydropalmatine exerts anxiolytic effects via potential interaction with the benzodiazepine binding site on the gamma-aminobutyric acid (GABAA) receptor.

Anti-inflammatory

L-tetrahydropalmatine exerts a prominent anti-inflammatory agent induced by lipopolysaccharide.

L-tetrahydropalmatine has been used for the treatment of headache and other mild pain. However, little is known about its analgesic effect on chronic pain and its mechanism. It was reported that L tetrahydropalmatine exerts remarkable antihyperalgesic effects on neuropathic and inflammatory pain in animal models.

Longevity

L tetrahydropalmatine has been reported to attenuate PTSD-induced changes in gene expression, such as those involving DA, serotonin, and acetylcholine, in the amygdala and hippocampus.

L-tetrahydropalmatine works as a powerful cardio-protective supplement, helping to prevent damage to the heart under a variety of stresses.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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