Is Lactobionic Acid the Same as Lactic Acid

The manufacturing of lactobionic acid involves hydrolyzing lactose to obtain galactose, followed by oxidation to convert galactose into lactobionic acid. The process is carefully controlled to produce a high-purity product suitable for use in cosmetics, pharmaceuticals, and other industries. While the traditional method relies on chemical oxidation, there is increasing interest in biotechnological production methods for a more sustainable, eco-friendly approach.

Is Lactobionic Acid the Same as Lactic Acid?

No, lactobionic acid and lactic acid are not the same, although they share a similar name. Here’s a breakdown of their differences:

• Lactic Acid: Lactic acid is an organic acid that occurs naturally in muscle cells during exercise or fermentation. It’s a product of glycolysis and is widely used in skincare products for its exfoliating and hydrating properties. Lactic acid is a hydroxy acid (alpha-hydroxy acid or AHA), commonly found in chemical peels, moisturizers, and serums to help remove dead skin cells, improve skin texture, and promote a radiant complexion.
• Lactobionic Acid: Lactobionic acid is a polyhydroxy acid (PHA), which is a newer generation of exfoliating acid. It’s derived from lactose (milk sugar) and is a more gentle exfoliant compared to lactic acid. Lactobionic acid has antioxidant properties and is known for its hydrating and anti-aging effects. It helps to improve skin texture without causing irritation, making it ideal for sensitive skin types.

In summary, while both are acids used in skincare, lactic acid is a more traditional AHA, and lactobionic acid is a PHA with additional benefits like hydration and less irritation.

Lactobionic Acid Manufacturing Process

1. Raw Material – Lactose

Lactose is the primary raw material used in the production of lactobionic acid. It is derived from milk or whey and is widely available as a byproduct of dairy processing. Lactose is a disaccharide sugar composed of glucose and galactose.

2. Hydrolysis of Lactose

The first step in the process involves hydrolyzing lactose to break it down into its two component monosaccharides: glucose and galactose. This can be done by adding acid or enzymes to break the bonds between glucose and galactose.

• Enzymatic Hydrolysis: In some methods, enzymes like lactase are used to catalyze the hydrolysis reaction. This method is more selective and controlled, producing high-purity glucose and galactose.
• Acid Hydrolysis: Alternatively, the hydrolysis can be achieved by treating lactose with a mild acid at elevated temperatures, leading to the separation of the glucose and galactose.

3. Oxidation of Galactose

Once lactose has been hydrolyzed into galactose and glucose, the next critical step is the oxidation of galactose to produce lactobionic acid. The oxidation process involves converting the aldehyde group in galactose into a carboxyl group, turning galactose into lactobionic acid.

• Oxidizing Agents: Typically, mild oxidizing agents such as bromine or sodium hypochlorite (NaOCl) are used to selectively oxidize galactose.
• Catalysts: In some cases, a metal catalyst, such as copper, may be used to improve the efficiency of the oxidation reaction.
• The oxidation process creates lactobionic acid (C6H12O7), which is a polyhydroxy acid (PHA) with both a carboxyl group and a hydroxyl group in its structure.

4. Purification

After the oxidation step, the crude lactobionic acid is typically purified to remove byproducts, residual reactants, and any impurities that may have formed during the process. The purification is usually achieved through methods like:

• Filtration: To remove solid impurities.
• Ion-Exchange: To remove unwanted ionic species and achieve high purity.
• Crystallization: Lactobionic acid may be crystallized out of solution to isolate the pure compound.

5. Concentration and Drying

Once purified, the lactobionic acid is concentrated and sometimes dried to achieve the desired form (liquid or powder), depending on the application.

• Concentration: This involves evaporating any remaining solvent or water from the product.
• Drying: In cases where powdered lactobionic acid is needed (e.g., for formulation in cosmetics or pharmaceuticals), the product may undergo spray-drying or freeze-drying.

6. Formulation and Packaging

Finally, the lactobionic acid is ready for use in various products, particularly skincare, cosmetic formulations, or even pharmaceutical applications. It can be sold as a pure ingredient or formulated into various products (e.g., serums, creams, or lotions) by mixing it with other active ingredients and stabilizers.

• Formulation: In the case of cosmetic and skincare products, lactobionic acid is often mixed with other active ingredients like moisturizers, antioxidants, or additional acids to enhance its effectiveness in exfoliating and hydrating the skin.
• Packaging: The finished lactobionic acid or its formulations are then packaged into bottles, jars, or tubes, depending on the product type.

Lactobionic acid raw material is produced by Essence Medchem Co., Ltd. Its purity can be over 98%. In stock U.S, Our have our own factory and can provide customized services according to customers’ requirements, as well as customized services such as OEM and ODM. We have aseptic production workshop to finished product processing workshop, which can produce tablets, capsules and also powder etc.

Why Lactobionic Acid Ingredients is Popular in Skincare？

Lactobionic acid has become popular due to its gentle nature, which makes it ideal for sensitive skin. Unlike harsher exfoliants like glycolic acid, lactobionic acid is a polyhydroxy acid (PHA), known for its larger molecular size, which means it exfoliates the skin without causing irritation. It also acts as a humectant, drawing moisture into the skin and leaving it hydrated, making it a good option for dry, aging, or delicate skin types. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a smoother, more radiant complexion.

Is Lactobionic Acid Good for Skin？

Yes, lactobionic acid is generally considered very beneficial for the skin. It is a polyhydroxy acid (PHA), which means it exfoliates the skin more gently compared to other acids like alpha-hydroxy acids (AHAs) or beta-hydroxy acids (BHAs). Here are the key benefits:

• Gentle Exfoliation: Lactobionic acid helps remove dead skin cells, which promotes smoother, brighter skin without causing irritation, making it ideal for sensitive skin.
• Hydration: It has excellent moisture-binding properties, meaning it helps to attract and retain water in the skin, making it beneficial for dry or dehydrated skin.
• Antioxidant Protection: Lactobionic acid also acts as an antioxidant, which helps protect the skin from free radical damage, which can lead to premature aging.
• Improved Skin Texture: It can help to refine the skin’s texture, making it look smoother and more radiant.
• Anti-Aging Effects: By promoting cell turnover and hydrating the skin, it helps reduce the appearance of fine lines and wrinkles.

Lactobionic Acid Before and After？

When using lactobionic acid consistently, users often notice improvements in skin texture and appearance over time. Here’s what you might expect before and after using products with lactobionic acid:

• Before:
  • Skin may appear dull, rough, or uneven.
  • You may have dry, flaky patches or experience occasional breakouts or irritation.
  • Fine lines and wrinkles may be visible, especially in areas prone to dryness.
• After:
  • Smoother skin: Lactobionic acid helps remove dead skin cells, which can lead to a smoother, more even complexion.
  • Radiant glow: The exfoliation and hydration it provides often result in more glowing, brighter skin.
  • Reduced fine lines: As the skin’s texture improves and dead skin cells are sloughed off, fine lines and wrinkles may appear less prominent.
  • Enhanced hydration: You may notice less dryness or flakiness due to its moisture-binding properties.
  • Even tone: Skin tone may become more uniform, and dark spots or hyperpigmentation may gradually fade with consistent use.

How to Use Lactobionic Acid？

Using lactobionic acid effectively in your skincare routine is relatively easy. Here’s how to incorporate it into your daily regimen:

1. Cleanse: Start by cleansing your skin with a gentle cleanser to remove makeup, dirt, and oils. This ensures the lactobionic acid can work more effectively on your skin.
2. Apply Lactobionic Acid:
   • If you’re using a toner or serum with lactobionic acid, apply it directly to the skin after cleansing.
   • If using a moisturizer that contains lactobionic acid, apply it as the last step in your routine, after serums or other treatments.
3. Allow Absorption: Let the product absorb fully into your skin before applying any other products or sunscreen.
4. Sunscreen: As with all exfoliants, it’s important to use sunscreen during the day, especially when using lactobionic acid, as your skin may become more sensitive to UV rays.

Frequency: Start with 2-3 times a week to allow your skin to adjust, and gradually increase to daily use if your skin tolerates it well. If you experience any irritation, reduce frequency.

Is Lactobionic Acid Safe？

Yes, lactobionic acid is generally considered safe for most people. Its mild nature, compared to other exfoliating acids like glycolic acid or salicylic acid, makes it suitable for sensitive skin types, including those with conditions like rosacea or eczema.

• Non-Irritating: Lactobionic acid is less likely to cause irritation, redness, or peeling compared to stronger acids, making it a great option for those who need a gentle exfoliant.
• Suitable for Sensitive Skin: It’s often used in products designed for sensitive or compromised skin due to its hydrating and soothing properties.
• Safe for Long-Term Use: With its gentler exfoliating effects, lactobionic acid can be safely incorporated into long-term skincare routines for many skin types.

As with any new ingredient, it’s recommended to patch-test products containing lactobionic acid to ensure you don’t have any sensitivities or allergies to the ingredient.

Is Lactobionic Acid Safe During Pregnancy?

Lactobionic acid is considered safe for use during pregnancy. Unlike some other skincare acids (like retinoids or salicylic acid), lactobionic acid is a mild exfoliant and is less likely to penetrate deeply into the skin. It is also a polyhydroxy acid (PHA), which is generally seen as safer than AHAs or BHAs due to its larger molecular size, which prevents deeper absorption.

What are Lactobionic Acid Side Effects？

While lactobionic acid is generally gentle and well-tolerated, there are a few potential side effects to be aware of:

• Mild Irritation: Although less likely than stronger acids, some people with very sensitive skin might experience mild redness, tingling, or irritation when first using lactobionic acid.
• Dryness: Since lactobionic acid is an exfoliant, it can potentially cause some dryness or tightness, especially if overused. It’s important to follow up with a good moisturizer.
• Sun Sensitivity: Like most exfoliating acids, lactobionic acid can make your skin more sensitive to the sun, so it’s essential to apply sunscreen daily while using products containing this acid.

If you experience significant irritation, redness, or other signs of an allergic reaction, stop using the product and consult a dermatologist.

Which brands use Lactobionic Acid Products？

Lactobionic acid is a relatively newer ingredient in the skincare world, but it has gained popularity due to its gentle exfoliating, hydrating, and anti-aging properties. As a polyhydroxy acid (PHA), it is especially well-suited for sensitive skin types. Various skincare brands have incorporated lactobionic acid into their formulations, often within serums, creams, masks, and cleansers. Below are some notable skincare brands that use lactobionic acid in their products:

1. Paula’s Choice

Paula’s Choice is known for offering effective, science-backed skincare, and they use lactobionic acid in some of their products, particularly in their exfoliation and anti-aging lines.

• Product Example:
  • Paula’s Choice Resist Advanced Smoothing Treatment 10% AHA contains a blend of AHAs, including lactobionic acid, to provide gentle exfoliation while boosting moisture retention and skin barrier function.

2. Neostrata

Neostrata is a brand that specializes in using alpha-hydroxy acids (AHAs) and polyhydroxy acids (PHAs) in their formulations, including lactobionic acid. Their products target skin rejuvenation, exfoliation, and anti-aging.

• Product Example:
  • Neostrata Bionic Face Cream: This moisturizer contains lactobionic acid as a key ingredient to improve skin texture and hydration while providing antioxidant benefits.

3. The Ordinary (Deciem)

The Ordinary, part of the Deciem brand, is known for its affordable, high-quality skincare products. While lactobionic acid is not featured in many of their products, some of their formulations incorporate PHAs, including lactobionic acid, as part of their gentle exfoliation options.

• Product Example:
  • The Ordinary PHA 3% + Lactic Acid 5%: This product features PHA (including lactobionic acid) alongside lactic acid to provide mild exfoliation while helping with skin hydration and smoothness.

4. Iredale (Jane Iredale)

Jane Iredale is a well-known brand that focuses on clean, skin-friendly makeup and skincare. Some of their skincare products, such as exfoliating treatments and masks, contain lactobionic acid for its gentle exfoliation and anti-aging effects.

• Product Example:
  • Iredale Hydration Spray: This product may include lactobionic acid for its humectant and antioxidant properties, helping to keep the skin hydrated and refreshed.

5. Skinceuticals

Skinceuticals is a professional-grade skincare brand that focuses on advanced formulations to improve skin health and fight aging. Some of their products include lactobionic acid due to its gentle exfoliating properties and hydrating effects.

• Product Example:
  • Skinceuticals Bionic Face Cream: This cream is formulated with lactobionic acid, providing gentle exfoliation while helping with moisture retention, skin tone improvement, and reducing visible signs of aging.

6. Meder Beauty (Meder Skincare)

Meder Beauty is known for its dermatological expertise and use of safe, effective ingredients. Lactobionic acid is often included in their anti-aging and hydrating formulations.

• Product Example:
  • Meder Beauty Anti-Aging Serum: This serum combines lactobionic acid with other ingredients to help improve skin texture, firmness, and hydration while reducing fine lines and wrinkles.

7. Dr. Dennis Gross

Dr. Dennis Gross is a dermatologist-driven brand that uses a variety of exfoliating acids in their products. Lactobionic acid, being a milder alternative to AHAs, is often featured in their products targeting sensitive or mature skin.

• Product Example:
  • Dr. Dennis Gross C+ Collagen Brighten & Firm Vitamin C Serum: While primarily focused on brightening and collagen support, this serum may also contain lactobionic acid as part of its skin-smoothing and anti-aging properties.

8. Dermalogica

Dermalogica is a professional skincare brand that focuses on high-performance, non-irritating formulas. Some of their products for sensitive or dry skin include lactobionic acid for exfoliation and skin hydration.

• Product Example:
  • Dermalogica Daily Superfoliant: This is an exfoliating powder that contains PHAs, including lactobionic acid, to help detoxify and smooth the skin while protecting it from environmental pollutants.

9. Alastin Skincare

Alastin Skincare offers products designed to rejuvenate the skin, often featuring advanced ingredients like PHAs. They use lactobionic acid in their formulations for its gentle exfoliating properties and ability to enhance skin texture and hydration.

• Product Example:
  • Alastin Skincare Restorative Skin Complex: This product combines lactobionic acid with other ingredients aimed at reducing the appearance of fine lines and wrinkles while improving skin firmness and tone.

10. Is Clinical

Is Clinical is known for their innovative skincare products that incorporate scientifically advanced ingredients. Lactobionic acid is used in their products to provide gentle exfoliation, particularly for sensitive or aging skin.

• Product Example:
  • iS Clinical Pro-Heal Serum Advance+: This serum, while primarily focused on healing and brightening, may also feature lactobionic acid to provide mild exfoliation and promote healthier skin. wholesale Cosmetic ingredients Contact Us.

References

• https://pmc.ncbi.nlm.nih.gov/articles/PMC10609777/
• https://www.sciencedirect.com/science/article/pii/S1568163724002241
• https://www.sciencedirect.com/topics/medicine-and-dentistry/lactobionic-acid
• https://www.verywellhealth.com/lactic-acid-skin-care-4178819
• https://pubmed.ncbi.nlm.nih.gov/20367666/