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Hydroxyproline
- Chemical Name: L-Hydroxyproline
- CAS No.:51-35-4
- MF: C5H9NO3
- MW:131.13
- Purity:>98% or As customer requested
- Color: White
- Product Categories: Amino Acids; Biochemistry; Nutritional Supplements; Pharmaceuticals
- Test method: HPLC
Description
What is Hydroxyproline?
Hydroxyproline is a nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen.
Increased hydroxyproline amino acid levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.
Basic information
| Product Name: | L-Hydroxyproline |
| Synonyms: | L-Hydroxyproline; trans-4-Hydroxyproline; Hypro; 4-hydroxyproline |
| CAS: | 51-35-4 |
| MF: | C5H9NO3 |
| MW: | 131.13 |
| EINECS: | 200-091-9 |
| Product Categories: | Amino Acids; Biochemistry; PHARMACEUTICALS; Biochemistry; Nutritional Supplements; |
Chemical Structure
Chemical Properties
| Melting point | 273 °C (dec.)(lit.) |
| alpha | -75.5 º (c=5, H2O) |
| Boiling point | 242.42°C (rough estimate) |
| density | 1.3121 (rough estimate) |
| vapor density | 4.5 (vs air) |
| refractive index | -75.5 ° (C=4, H2O) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 50 mg/mL |
| form | Crystals or Crystalline Powder |
| pka | 1.82, 9.66(at 25℃) |
| color | White |
| PH | 5.5-6.5 (50g/l, H2O, 20℃) |
| Odor | Odorless |
| optical activity | [α]25/D 75.6°, c = 1 in H2O |
| Water Solubility | 357.8 g/L (20 º C) |
| Merck | 14,4840 |
| BRN | 471933 |
| InChIKey | PMMYEEVYMWASQN-DMTCNVIQSA-N |
Usage And Synthesis
| Description | A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys. |
| Chemical Properties | White crystalline powder |
Hydroxyproline Uses
Hydroxyproline is a non-essential amino acid separated from another amino acid called proline. It is produced by the interaction of proline and vitamin C ascorbic acid. This process produces hydroxyl groups bound to hydrogen and oxygen molecules, which are connected to the carbon molecules of proline and converted into hydroxyproline amino acid.
This amino acid was first separated from the gel in 1902. It is one of the 22 amino acids required to form human protein and is also part of the standard human genetic code. Hydroxyproline is produced in the gastrointestinal tract.
Without vitamin C, it is impossible to produce hydroxyproline amino acid. Without it, serious problems will arise, because the body cannot produce collagen(the most important protein structure). Both proline and hydroxyproline are important for the formation of this key substance, and the lack of either will cause serious instability of collagen in the body.
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
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