Hydrocortisone

Description

What is Hydrocortisone?

Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.

Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses.

Basic information

Product Name:	Hydrocortisone
Synonyms:	Cortisol; Hydrasson; Hydrocortisyl;
CAS:	50-23-7
MF:	C21H30O5
MW:	362.47
EINECS:	200-020-1
Product Categories:	Pharmaceutical intermediates; Intermediates& Fine Chemicals; Inhibitors; Pharmaceuticals; API

Chemical Structure

Hydrocortisone

Chemical Properties

Melting point	211-214 °C(lit.)
alpha	166 º (c=1, C2H5OH 25 ºC)
Boiling point	414.06°C (rough estimate)
density	1.0812 (rough estimate)
refractive index	1.6120 (estimate)
Fp	220°C
storage temp.	-20°C
solubility	H₂O: 100 mg/mL
form	powder
color	White
Water Solubility	319.7mg/L(25 ºC)
Decomposition	220 ºC
Merck	14,4787
BRN	1354819
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

Hydrocortisone Uses And Synthesis

Chemical Properties	crystalline white powder
Uses	Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.
	glucocorticoid, antiinflammatory
	Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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