Gentamycin sulfate of the roles

Gentamicin (trade name Garamycin) is an antibiotic that has a therapeutic effect on both gram-positive and gram-negative bacteria. Indications include bone infection, endocarditis, pelvic inflammation, meningitis, pneumonia, urinary tract infection, and sepsis, etc. This article introduces the role and efficacy of gentamicin, as well as the oral problems of gentamicin.

How About the role and efficacy of gentamicin?

Gentamicin is an aminoglycoside antibiotic. It is a static bactericide. It mainly inhibits the synthesis of bacterial protein to achieve the purpose of bactericidal. It has the advantages of strong bactericidal power, high bioavailability, wide tissue distribution, and good permeability. Both randella-positive and negative bacteria have antibacterial activity, especially against Gram-negative Enterobacteria, and it also has good antibacterial effect against Staphylococcus aureus and other Gram-positive bacteria, but against Streptococcus pneumoniae, etc. Streptococcus is less effective.

Gentamicin is mainly available in oral and injection forms. Gentamicin administered orally is rarely absorbed locally in the intestinal tract, and can form high concentrations in the intestinal tract. It can be used to treat bacterial intestinal infections, such as acute bacillary dysentery. It can also be used for intestinal preparation before colon surgery to prevent surgical incision infections, while injection of gentamicin can be used to treat lower respiratory tract infections such as bronchitis and pneumonia caused by sensitive bacteria, bacterial intestinal infections, abdominal infections, etc. Pelvic infections, skin and soft tissue infections and complicated urinary tract infections, etc., when treating abdominal infections and pelvic infections, it should be combined with anti-anaerobic drugs such as metronidazole and clindamycin. In clinical practice, gentamicin is often combined with other antibacterial drugs. Use, such as combined with penicillin antibiotics such as amoxicillin and ampicillin to treat enterococcal infections.

Gentamicin Indications

This product is mainly used to treat aerobic gram-negative bacilli, including lower respiratory tract infections, intra-abdominal infections, soft tissue infections, wound infections, complicated urinary tract infections, meningitis, bacterial heart caused by some enterobacteria and Pseudomonas aeruginosa. Endometritis, mild conjunctivitis, keratitis, etc.

In the treatment of meningitis, in addition to injections, intrathecal administration or intracerebroventricular injection is often used. This product is often combined with penicillin G (or ampicillin) to treat infections caused by Enterococcus and Streptococcus viridans.

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