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Erythromycin Estolate
- Chemical Name:Erythromycin Estolate
- CAS No.:3521-62-8
- MF: C52H97NO18S
- MW:1056.39
- Specification: USP|EP|BP
- Purity: 95%-99% or As customer requested
- Appearance: White
- Solubility：Freely soluble in organic solvents, practically insoluble in water /n
- Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
- Test method: HPLC
Description
Erythromycin Estolate is the lauryl sulfate ester of propionyl erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin estolate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin estolate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. (Source: NCI Thesaurus (NCIt))
Ilosone Basic information
| Product Name: | Erythromycin Estolate |
| Synonyms: | eritroger;eromycin;erythromycin,propionate(ester),compd.withmonododecylsulfate(1:1);erythromycin5-(3-propionate)dodecylsulfate;erythromycinpropionate,compd.withdodecylsulfate;erythromycinpropionatelaurylsulfate;ERYTHROMYCIN ESTOLATE;ERYTHROMYCIN 2′-PROPANOATE DODECYL SULFATE SALT |
| CAS: | 3521-62-8 |
| MF: | C52H97NO18S |
| MW: | 1056.39 |
| EINECS: | 222-532-4 |
| Product Categories: | Intermediates & Fine Chemicals; Pharmaceuticals |
| Mol File: | 3521-62-8.mol |
Lauromicina Chemical Structure
Estomicina Chemical Properties
| Melting point | 135-140°C dec. |
| Boiling point | 743℃ |
| density | 1.0053 (rough estimate) |
| refractive index | 1.6550 (estimate) |
| Fp | >110°(230°F) |
| storage temp. | -20°C Freezer |
| solubility | chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform) |
| pka | 6.9(at 25℃) |
| form | neat |
| color | white |
| Water Solubility | Freely soluble in organic solvents, practically insoluble in water /n |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 3521-62-8 |
Erythromycin Estolate Usage And Synthesis
| Uses | Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats |
| Macrolides Antibiotics | |
| Manufacturing Process | 16.7 grams of monopropionylerythromycin are dissolved in 50 ml of warm acetone. To the solution are added 6.4 grams of sodium lauryl sulfate dissolved in 50 ml of distilled water containing 2 ml of glacial acetic acid. The white crystalline precipitate of rnonopropionylerythromycin lauryl sulfate which separates is filtered off and dried. It melts at about 135° to 137°C. |
| Therapeutic Function | Antibacterial |
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
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