Entecavir

Description

What is Entecavir?

Entecavir Anhydrous is an anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.

Basic information

Product Name:	Entecavir
Synonyms:	Entecavir USP; Entecavir INN
CAS:	142217-69-4
MF:	C12H15N5O3
MW:	277.28
EINECS:	604-279-5
Product Categories:	>Pharmaceutical raw materials; APIs; Synthetic Anti-infective Drugs

Chemical Structure

Entecavir

Chemical Properties

Melting point: 249-252°C

Boiling point: 661.4±65.0 °C(Predicted)

density: 1.81±0.1 g/cm3(Predicted)

storage temp.: -20°C

pka: 14.22±0.60(Predicted)

form: powder

color:white to beige

Entecavir Uses

Entecavir is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.

Patients with chronic hepatitis B should be under the guidance of experienced doctors taking this product. Recommended dosage: adult and over the age of 16 young oral this product, once a day, each 0.5 mg. lamivudine treatment viremia or patients with lamivudine resistant mutants to once a day, each 1.0 mg (0.5mg two pieces), taken on an empty stomach (a meal or a meal after at least 2 hours).

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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