Demeclocycline Hydrochloride

Description

Demeclocycline hydrochloride is the hydrochloride salt of demeclocycline. A tetracycline antibiotic, it is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It has a role as an antibacterial drug. It contains a demeclocycline.

Demeclocycline hydrochloride Basic information

Product Name:	Demeclocycline hydrochloride
Synonyms:	7-CHLORO-6-DEMETHYLTETRACYCLINE HYDROCHLORIDE; DEMECLOCYCLINE; DEMECLOCYCLINE HYDROCHLORIDE; chlorodemethyltetracyclin hydrochloride;
CAS:	64-73-3
MF:	C21H21ClN2O8.ClH
MW:	501.32
EINECS:	200-592-2
Product Categories:	API; Intermediates & Fine Chemicals; Pharmaceuticals; Amines;

Demeclocycline hydrochloride Chemical Structure

Demeclocycline hydrochloride

Demeclocycline hcl Chemical Properties

Melting point	>245°C (dec.)
storage temp.	−20°C
solubility	H₂O: 20 mg/mL, clear, very deep greenish yellow
pka	pKa 3.3 (Uncertain)
form	powder
Water Solubility	Soluble in water.
Merck	13,2905
BRN	5705221
InChIKey	GVSJQNRGSCOSNJ-KBHRXELFSA-N

Demeclocycline hcl Usage And Synthesis

Chemical Properties	Yellow Solid
Uses	An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time
	Antibacterial; Ribosomal protein synthesis inhibitor
	Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.