Clindamycin

Description

What is Clindamycin?

Clindamycin is a lincosamide antibiotic, usually used to treat anaerobic bacterial infections, but it can also treat protozoal diseases such as malaria. It is a commonly used topical prescription for acne and can effectively treat drug-resistant Staphylococcus aureus (MRSA) infections.

Clindamycin, a derivative of lincomycin, was fi rst isolated from Streptomyces lincolnesis in 1962 and became commercially available in 1966. It replaced lincomycin use because of its better absorption and clinical spectrum. It is active against gram-positive, gram-negative, and anaerobic organisms.

Basic information

Product Name:	Clindamycin
Synonyms:	Chlolincocin; Dalacine; Sobelin; Clindamycin hydrochloride; Clindamycine; Clindamycinum; Clindamicina
CAS:	18323-44-9
MF:	C18H33ClN2O5S
MW:	424.98
EINECS:	242-209-1
Product Categories:	Inhibitors; Antibiotics; APIs; Lincosamides Drugs

Chemical Structure

Chemical Properties

alpha	D +214° (chloroform)
Boiling point	134°C (rough estimate)
density	1.1184 (rough estimate)
refractive index	1.6100 (estimate)
pka	7.6(at 25℃)

Usage And Synthesis

Clindamycin Uses

Clindamycin is effective in the treatment of most infections secondary to anaerobes and gram-positive cocci. It can be used for anaerobic pulmonary, intra-abdominal, gynecologic, pelvic, diabetic foot, and decubitus ulcer infections. Another appropriate agent should be added since the majority of these infections are polymicrobial. It can also be used as an alternative agent for patients with severe penicillin allergy. It is also used to treat Clostridium perfringens infection.

Clindamycin Side Effects

The most commonly observed adverse effect is diarrhea. The reported incidence of C. difficile colitis in patients treated with clindamycin varies from 0.1 to 10%. The syndrome may be fatal. If the patient develops C. difficile colitis, clindamycin should be discontinued and the patient should be treated for C. difficile . Other side effects include rash, nausea, vomiting, diarrhea, flatulence, abdominal distension, anorexia, and transient elevation of liver enzymes. Other less common events, such as fever, neutropenia, thrombocytopenia, and eosinophilia have been reported.