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Citicoline
- Chemical Name: Citicoline
- CAS No.:987-78-0
- MF: C14H26N4O11P2
- MW: 488.32
- Purity:>99% or As customer requested
- Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;APIs; Pharma Intermediates
- Test method: HPLC
Description
What is Citicoline?
Citicoline is a nutritional supplement and source of choline and cytidine with potential neuroprotective and nootropic activity. Citicoline, also known as cytidine-5-diphosphocholine or CDP-choline, is hydrolyzed into cytidine and choline in the intestine. Following absorption, both cytidine and choline are dispersed, utilized in various biosynthesis pathways, and cross the blood-brain barrier for resynthesis into citicoline in the brain, which is the rate-limiting product in the synthesis of phosphatidylcholine. This agent also increases acetylcholine (Ach), norepinephrine (NE) and dopamine levels in the central nervous system (CNS). In addition, citicoline is involved in the preservation of sphingomyelin and cardiolipin and the restoration of Na+/K+-ATPase activity. Citicoline also increases glutathione synthesis and glutathione reductase activity, and exerts antiapoptotic effects. (Source: NCI Thesaurus (NCIt))
Basic information
| Product Name: | Citicoline |
| Synonyms: | CYTIDINE 5′-DIPHOSPH; Cytidine 5′-(trihydrogen diphosphate); Difosfocin; Emicholine; CYTIDINE 5′-DIPHOSPHOCHOLINE; CDP-choline |
| CAS: | 987-78-0 |
| MF: | C14H26N4O11P2 |
| MW: | 488.32 |
| EINECS: | 213-580-7 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;APIs; Pharma Intermediates |
Chemical Structure
Chemical Properties
| alpha | D25 +19.0° (c = 0.86 in H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 4.4(at 25℃) |
Usage And Synthesis
| Uses | antidepressant, 5HT uptake inhibitor |
| Therapeutic Function | Cerebral circulation stimulant |
Citicoline application
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Mainly used for acute traumatic brain injury and disturbance of consciousness after brain surgery.
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Impairment of consciousness in the acute phase of cerebral infarction.
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It can be used for ischemic cerebrovascular disease, vascular dementia, tinnitus and neurological deafness.
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It can also be applied to coma and disturbance of consciousness caused by acute poisoning, infection and large-area cerebral infarction.
Technical Support & Resources
Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
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