Chlorogenic acid’s application

Chlorogenic acid has a wide range of biological activities. The research on the biological activity of chlorogenic acid has been carried out in many fields such as food, health care, medicine and daily chemical industry. Chlorogenic acid is an important bioactive substance, which has the functions of anti-bacterial, anti-virus, increasing white blood cells, protecting liver and cholagogue, anti-tumor, lowering blood pressure, lowering blood lipid, scavenging free radicals and exciting the central nervous system.

Chlorogenic acid’s application

Antibacterial and antiviral

Eucommia chlorogenic acid has strong antibacterial and anti-inflammatory effects, aucubin and its polymer have obvious antibacterial effects, and aucubin has inhibitory effects on both gram-negative and positive bacteria. The aucubin has bacteriostatic and diuretic effects, and can promote wound healing; After pre culture together with glucoside, aucubin can also produce obvious antiviral effect, but it itself has no antiviral function. The Institute of Aging Medical Science of Aichi Medical University in Japan has confirmed through research that the alkaline substance extracted from Eucommia ulmoides has the function of resisting viruses that damage the human immune system, and this substance may be used to prevent and treat AIDS.

Antioxidation

Chlorogenic acid is an effective phenolic antioxidant. Its antioxidant capacity is stronger than caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxyanisole (BHA) and tocopherol. The reason why chlorogenic acid has antioxidant effect is that it contains a certain amount of R-OH group, which can form hydrogen free radicals with antioxidant effect to eliminate the activity of hydroxyl free radicals and superoxide anion and other free radicals, so as to protect tissues from oxidative damage.

Scavenge free radicals, anti-aging, anti-aging of muscles and bones

Chlorogenic acid and its derivatives have stronger free radical scavenging effect than ascorbic acid, caffeic acid and tocopherol (vitamin E), can effectively eliminate DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and can also inhibit the oxidation of low-density lipoprotein. Chlorogenic acid plays an important role in effectively eliminating free radicals in the body, maintaining the normal structure and function of body cells, preventing and delaying the occurrence of tumor mutation and aging. Eucommia chlorogenic acid contains a special component that can promote the synthesis and decomposition of collagen in human skin, bones and muscles. It has the functions of promoting metabolism and preventing decline. It can be used to prevent the decline of bones and muscles caused by space weightlessness of astronauts. It is also found that eucommia chlorogenic acid has obvious anti free radical effects both in vivo and in vitro.

Mutation inhibition and anti-tumor

Modern pharmacological experiments have proved that eucommia chlorogenic acid has anti-cancer and anti-tumor effects. Japanese scholars have studied the antigenicity of eucommia chlorogenic acid, and found that this effect is related to chlorogenic acid and other antigenicity components, revealing the important significance of chlorogenic acid in tumor prevention.

Polyphenols in vegetables and fruits, such as chlorogenic acid and caffeic acid, can inhibit the mutagenicity of carcinogens aflatoxin B1 and benzo [a] – pyrene by inhibiting activating enzymes; Chlorogenic acid can also prevent and fight cancer by reducing the utilization rate of carcinogens and their transport in the liver. Chlorogenic acid has significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered to be an effective chemical protective agent for cancer.

Cardiovascular protection

As a free radical scavenger and antioxidant, chlorogenic acid has been proved by a large number of experiments that this biological activity of chlorogenic acid can protect the cardiovascular system. Isochlorogenic acid B can strongly promote the release of prostacyclin (PGI2) and inhibit platelet aggregation in rats; The inhibition rate of SRS-A release induced by antibodies induced by guinea pig lung fragments was 62.3%. Isochlorogenic acid C can also promote PGI2 release. In addition, Isochlorogenic acid B has a strong inhibitory effect on thromboxane biosynthesis and endothelin damage induced by hydrogen peroxide.

Other biological activities

Because chlorogenic acid has a special inhibitory effect on hyaluronic acid (HAase) and glucose-6-phosphatase (Gl-6-Pase), chlorogenic acid has certain effects on wound healing, healthy and moist skin, lubrication of joints, prevention of inflammation, and balance regulation of blood sugar in the body. Chlorogenic acid also has strong inhibition and killing effects on many diseases and viruses. Chlorogenic acid has pharmacological effects such as lowering blood pressure, anti-bacterial, anti-virus, anti-inflammatory, increasing white blood cells, preventing diabetes, significantly increasing gastrointestinal peristalsis and promoting gastric juice secretion, and has obvious effects on acute throat inflammation. Studies have shown that oral chlorogenic acid can significantly stimulate the secretion of bile, with the effect of cholagogic and liver protective; It can also effectively inhibit the hemolysis of rat erythrocytes induced by H2O2.