Chlorogenic Acid Caffeine

Description

What is Chlorogenic Acid Caffeine?

Chlorogenic acid caffeine (CA) is a phenolic compound broadly tracked down in products of the soil (apples, pears, carrots, tomatoes, and yams) and in espresso and tea.71 Recent proof exhibited the searching, cell reinforcement, and antiapoptotic action of wholesale chlorogenic acid.72 In a murine model of cisplatin (CP)- prompted AKI,72 the chlorogenic acid caffeine intraperitoneally infused 48 hours after the CP infusion recuperated renal capability and decreased renal histologic irregularities concerning cylindrical rot, cast collection, and rounded dilatation.

The wholesale chlorogenic acid-actuated histology improvement resembled the decrease of renal oxidative pressure and aggravation, as shown by the diminished articulation of cyclooxygenase-2 (COX-2) and growth corruption factor-α (TNF-α). Also, chlorogenic acid caffeine displayed a restraining impact on apoptosis and autophagy, as recommended by the concealment of p53, caspase-3, cyclin D1, and microtubule-related protein 1 light chain 3 isoform B (LC3B) articulation.

Basic information of Chlorogenic acid

Product Name:	Chlorogenic acid
Synonyms:	(1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxy-cyclohexane-1-carboxylic acid;CHLOROGENID ACID;CHLOROGENIC ACID(AHP);3-CAFFEOLYQUINICACID;3-[[3-(3,4-dihydroxyphenyl)-1-oxy-2-propenyl]oxy]-1,4,5-trihydroxy-1,[1S-(1 a , 3 β , 4 a , 5 a )];Chlorogenic Acid Hydrate;Cyclohexanecarboxylic acid,3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)- 1,4,5-trihydroxy-,(1S-(1-alpha,3-beta,4-alpha,5-alpha));Heriguard
CAS:	327-97-9
MF:	C16H18O9
MW:	354.31
EINECS:	206-325-6
Product Categories:	natural product;Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Plant Oils, Toxins, Phenolic Acids & Derivatives;Natural Plant Extract;Plant extract;Plant extracts;Herb extract;standardized herbal extract;caffeic acid;Chlorogenic acid;The group of Chlorogenic acid
Mol File:	327-97-9.mol

Caffeoylquinic Acids Chemical Structure

Chlorogenic acid

Chlorogenic Acid Hydrate Chemical Properties

Melting point	210 °C (dec.) (lit.)
alpha	-36 º (c=1, H2O)
Boiling point	407.55°C (rough estimate)
density	1.3594 (rough estimate)
refractive index	-37 ° (C=1, H2O)
storage temp.	0-6°C
solubility	Soluble in ethanol and acetone.
pka	3.91±0.50(Predicted)
form	Powder, Crystals, Needles and/or Chunks
color	White to almost white
Water Solubility	SOLUBLE IN HOT WATER
Merck	14,2142
InChIKey	CWVRJTMFETXNAD-JUHZACGLSA-N
CAS DataBase Reference	327-97-9(CAS DataBase Reference)
EPA Substance Registry System	Chlorogenic acid (327-97-9)

Chlorogenic Acid Caffeine Benefits

1. Chlorogenic Acid Appears To Reduce Blood Pressure

There have been numerous studies investigating the link between chlorogenic acid caffeine and blood pressure;

A randomized, controlled trial demonstrated that 140 mg per day of wholesale chlorogenic acid could decrease blood pressure. In this study, all participants who took chlorogenic acid had “significantly reduced” blood pressure readings shortly after ingestion compared to placebo

2. Chlorogenic Acid May Improve Glucose Regulation

Clinical trials demonstrate that wholesale chlorogenic acid intake lowers fasting levels of glucose and insulin levels, as well as lowering the postprandial response.

3. May Protect Against Heart Disease and Atherosclerosis

Human studies show that chlorogenic acid can reduce some of the risk factors for cardiovascular disease. Animal studies go one step further, and they demonstrate that chlorogenic acid caffeine helps prevent atherosclerosis.