Cefaclor Monohydrate

Description

Cefaclor Monohydrate Introduction

Cefaclor Monohydrate is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefaclor Monohydrate binds to and inactivates penicillin-binding proteins (PBP) located in bacterial cytoplasmic membranes.

PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of Cefaclor Monohydrate interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Ceclor Basic information

Product Name:	Cefaclor monohydrate
Synonyms:	(7R)-3-Chloro-7-[[(R)-aminophenylacetyl]amino]cepham-3-ene-4-carboxylic acid sodium salt;Muco-panoral; (6R,7R)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3-chloro-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate; (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate; (6R,7R)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate; Cefaclor (400 mg); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-phenylacetyl]aMino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7R)-; CEFACLOR HYDRATE
CAS:	70356-03-5
MF:	C15H16ClN3O5S
MW:	385.82
EINECS:	641-991-5
Product Categories:	Heterocycles; Intermediates & Fine Chemicals; Chiral Reagents; Pharmaceuticals; Sulfur & Selenium Compounds
Mol File:	70356-03-5.mol

Distaclor Chemical Structure

Cefaclor monohydrate

Alfatil Chemical Properties

Melting point	>180°C (dec.)
storage temp.	-20?C Freezer
solubility	Slightly soluble in water, practically insoluble in methanol and in methylene chloride.
form	neat
CAS DataBase Reference	70356-03-5(CAS DataBase Reference)

Cefaclor Monohydrate Usage And Synthesis

Chemical Properties	Crystalline Solid
Uses	Antibacterial; Bacterial transpeptidase inhibitor
Uses	Second-generation cephalosporin antibiotic. Antibacterial
Contact allergens	Cefaclor is a semisynthetic cephalosporin antibiotic, related to cefalexin, and a frequent inducer of serum sickness-like reactions.