Briefing of 4-Dimethylamino Antipyrine-d6

Briefing of 4-Dimethylamino Antipyrine-d6

Molecular formula

• C13H17N3O

• 4-[Bis(trideuteriomethyl)amino]-1,5-dimethyl-2-phenylpyrazol-3-one

• 4-Dimethylaminoantipyrine-d6

• 4-[di(?H?)methylamino]-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one

Molecular weight

237.33 g/mol

typical smile

CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)C

smiling smile

[2H]C([2H])([2H])N(C1=C(N(N(C1=O)C2=CC=CC=C2)C)C)C([2H])([2H] )[2H]

molecular formula

C13H17N3O

4-(Dimethylamino)antipyrine, 98+%, Thermo Scientific Chemicals

4-Dimethylamino Antipyrine

Product Description

Tramadol

Tramadol, sold under brand names such as Ultram is an opioid pain reliever used to treat moderate to moderate pain.Pain relief usually begins within one hour when given orally in the immediate-release formulation.It can also be obtained by injection.It can be used in combination with paracetamol (acetaminophen).As with typical opioids, common side effects include constipation, itching, and nausea.Serious side effects may include hallucinations, seizures, increased risk of serotonin syndrome, decreased alertness, and drug addiction.For those with kidney or liver problems, dosage changes may be recommended.Not recommended for those at risk of suicide or those who are pregnant.Although not recommended for breastfeeding women, women taking a single dose usually do not have to stop breastfeeding.Tramadol is converted in the liver to O-desmetramadol (desmetramadol), an opioid with a stronger affinity for the μ-opioid receptor.Tramadol is also a serotonin-norepinephrine reuptake inhibitor (SNRI).Tramadol was patented in 1963 and launched under the name “Tramal” in 1977 by the West German pharmaceutical company.Approved in the UK and US in the mid-1990s .It is available as a generic drug and sold under many brand names worldwide.In 2020, it was the 35th most commonly prescribed drug in the United States, with more than 17 million prescriptions filled.

Medical use

Generic tramadol hydrochloride tablets sold by Amneal Pharmaceuticals

Tramadol Hydrochloride for Injection:

Tramadol (Class IV drug in the US) is mainly used for the treatment of mild to severe acute and chronic pain.There is moderate evidence for use as a second-line treatment for fibromyalgia, but it is not FDA-approved for this use.It is approved by the NHS as a secondary pain reliever in the treatment of fibromyalgia.Its analgesic effect takes about an hour to develop and peaks in two to four hours after oral administration of the immediate-release formulation.On a dose-by-dose basis, tramadol was approximately one-tenth as potent as morphine (so 100 mg was equivalent to 10 mg Tramadol is nearly as potent as peine.For pain of moderate severity, the effectiveness was roughly equivalent to low doses of codeine and very high doses of hydrocodone. For severe pain, it is not as effective as morphine.The pain-reducing effect lasts for about six hours.The effectiveness of pain relief varies widely because it depends on an individual’s genetics. People with certain CYP2D6 enzyme variants may not produce sufficient amounts of the active metabolite (desmetremadol) to effectively control pain.Sleep medicine physicians sometimes prescribe tramadol (or other opioids) for refractory restless legs syndrome (RLS);that is, first-line Poor response to drug therapy in RLS ) or alpha-2-delta (α2δ) ligands (gabapentinoids), usually due to enhancement.