Benzydamine Hydrochloride

Description

What is Benzydamine Hydrochloride?

Benzydamine Hydrochloride is an indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties. (Source: NCI Thesaurus (NCIt)

Benzydamine Hydrochloride Product Description

Product Name:	Benzydamine hydrochloride
Synonyms:	LABOTEST-BB LT00771795;BENZYDAMINE HCL;BENZYDAMINE HYDROCHLORIDE;1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE;epirotin;imotryl;indolin;n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro
CAS:	132-69-4
MF:	C19H23N3O.ClH
MW:	345.87
EINECS:	205-076-0
Product Categories:	ROBINUL;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate
Mol File:	132-69-4.mol

BENZYDAMINE HCL Chemical Structure

Benzydamine hydrochloride

Imotryl Chemical Properties

Melting point	147-153°C
storage temp.	2-8°C
form	neat
Water Solubility	Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
Merck	14,1122
InChIKey	HNNIWKQLJSNAEQ-UHFFFAOYSA-N
CAS DataBase Reference	132-69-4(CAS DataBase Reference)

Indolin Manufacturing Process

To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.

In practice it is usually used as monohydrochloride salt.

Benzydamine Hydrochloride Side Effects

The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.

Email us at: info@maxmedchem.com