L-Glutamine

Description

What is L-glutamine?

Glutamine is a nonessential amino acid. Glutamine can donate the ammonia on its side chain to the formation of urea (for eventual excretion by the kidneys) and to purines (necessary for the synthesis of nucleic acids). Glutamic acid-to-glutamine conversion, in which an ammonia group is added to glutamic acid (catalyzed by glutamine synthase), is of central importance in the regulation of toxic levels of ammonia in the body. This agent is a substrate for the production of both excitatory and inhibitory neurotransmitters (glutamate and GABA) and is also an important source of energy for the nervous system. Glutamine may become a conditionally essential amino acid during certain catabolic states.

L-glutamine is an essential amino acid and precursor of major intracellular antioxidant molecules that is used in high doses to prevent vaso-occlusive crises in patients with sickle cell disease. L-glutamine has not been associated with serum enzyme elevations during therapy or to instances of idiosyncratic acute liver injury.

Basic information

Product Name:	L-Glutamine
Synonyms:	2,5-Diamino-5-oxpentanoicacid; LEVOGLUTAMIDE; L(+)-GLUTAMINE; L-GLUTAMINE; L(+)-GLUTAMIC ACID-5-AMIDE; L-GLUTAMIC ACID 5-AMIDE; L-GLUTAMIC ACID AMIDE; L-GLN
CAS:	56-85-9
MF:	C5H10N2O3
MW:	146.14
EINECS:	200-292-1
Product Categories:	Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids; APIs; Biochemical Engineering

Chemical Structure

L-Glutamine

Chemical Properties

Melting point	185 °C (dec.) (lit.)
alpha	32.25 º (c=10, 2 N HCl)
Boiling point	265.74°C (rough estimate)
density	1.47 g/cm3 (20℃)
FEMA	3684 \| L-GLUTAMINE
refractive index	6.8 ° (C=4, H2O)
Fp	185°C
storage temp.	Store below +30°C.
solubility	H₂O: 25 mg/mL
pka	2.17(at 25℃)
form	solution
color	White
PH	5.0-6.0 (25℃, 0.1M in H2O)
optical activity	[α]20/D +33.0±1°, c = 5% in 5 M HCl
Water Solubility	Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform.
λmax	λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01
Decomposition	185 ºC
JECFA Number	1430
Merck	14,4471
BRN	1723797
Stability:	Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents.
InChIKey	ZDXPYRJPNDTMRX-VKHMYHEASA-N

Usage And Synthesis

Chemical Properties

White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C.

L-Glutamine Uses

The product transforms into glycosamine in the body, as a precursor of synthetic mucin, can promote ulcer healing, and is mainly used as a peptic ulcer medicine. In addition, it can also be used as a brain function improving agent and for the treatment of alcoholism.

2. Used to improve the brain function of children with mental retardation and mental disorders, alcoholism and epilepsy.

3. Nutritional supplements. In medicine, it is used to treat peptic ulcers (gastric ulcer, duodenal ulcer), acute and chronic gastritis. It is also used as a brain function improving agent and treatment of alcoholism.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.