Colistin Sulfate

Description

Colistin sulfate, a cationic polypeptide from the polymyxin family, has been demonstrated to be an incredibly powerful anti-infection that is viable against most gram-negative Bacilli.

Robotic investigations have detailed that this compound prompts apoptosis through association with the cytoplasmic layer. Extra examinations have exhibited that Colistin sulfate is incredibly poisonous. Poisonous impacts noted incorporate neurotoxicity, nephrotoxicity, vascular clog of mind vessels, and outrageous kidney and CNS adverse consequences.

Colistin sulfate Basic information

Product Name:	Colistin sulfate
Synonyms:	belcomycin; Animal Feed Additives colistin sulfate Colistin Sulfate; Animal Feed Additives colistin sulfate CAS 1264-72-8 Colistin Sulfate; COLISTINE SULFATE; COLISTIN SULPHATE PURE GRADE; Colistin sulphate premix 10% 40%; Polymyxin E . sulfate
CAS:	1264-72-8
MF:	2(C52H98N16O13).5(H2SO4)
MW:	2801.27
EINECS:	215-034-3
Product Categories:	Intermediates & Fine Chemicals; Pharmaceuticals; Active Pharmaceutical Ingredients; Veterinaries; SYNCURINE; antibiotic; API; Inhibitors

Colistin sulfate Chemical Structure

Colistin sulfate

Colistin sulphate Chemical Properties

Melting point	200-220°C
storage temp.	2-8°C
solubility	H2O: soluble50mg/mL
form	powder
PH	4.0～6.0（10g/l, 25℃）
Water Solubility	Soluble in water
Merck	14,2479
InChIKey	VEXVWZFRWNZWJX-NBKAJXASSA-N

Colistin sulphate Usage And Synthesis

Chemical Properties	White or almost white, hygroscopic powder.
Uses	antibacterial
Uses	neuromuscular blocker
Clinical Use	Colistimethate sodium Infections due to Ps. aeruginosa and other Gram-negative rods resistant to less toxic agents Cystic fibrosis (inhalation therapy for pseudomonas infection) Polymyxin B and colistin sulfate Component of preparations for local application Superficial infections with Ps. aeruginosa and to prevent the colonization of burns Selective decontamination of the gut and as a paste for control of upper respiratory tract colonization in patients on prolonged mechanical ventilation (in combination with other agents)