Cefixime Trihydrate

Description

Cefixime Trihydrate is a broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity.

As does penicillin, the beta-lactam antibiotic Cefixime Trihydrate inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.

Cefixime Trihydrate, also known as cephalosporin, which belongs to the third-generation oral cephalosporin antibiotics with a broad antibacterial spectrum. It is for some gram-negative and gram-positive bacteria. All have a certain antibacterial effect. Its mechanism is mainly through inhibiting the synthesis of bacterial cell wall, which can play a bactericidal effect.

The dispersible tablet refers to a tablet that can be quickly disintegrated and uniformly dispersed in water, and has the characteristics of convenient taking, rapid disintegration, fast absorption and high bioavailability. Therefore, cefixime dispersible tablets are absorbed faster than capsule and tablet types of cefixime.

Basic Information

Product Name:	Cefixime Trihydrate
Synonyms:	CEFIXME TRIHYDRATE; Cefixime hydrate; Cefixime
CAS:	79350-37-1
MF:	C16H15N5O7S2
MW:	453.45
EINECS:	616-684-4
Product Categories:	Pharmaceutical raw materials;APIs;Antibiotics;Cephalosporins Drugs

Chemical Structure

cefixime Trihydrate

Chemical Properties

Melting point	218-225°C
density	1.85±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate.
pka	pKa 2.10 (Uncertain)
Water Solubility	55.11 mg/L

Cefixime Trihydrate Uses

Clinically used for the treatment of Streptococcus (except Enterococcus), Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Branhamococcus catarrhalis, Serratia, Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Bacterial infectious diseases caused by Haemophilus influenzae…etc.

The indications are as follows:

1. Respiratory system infections, such as pneumonia, tonsillitis, pharyngitis, bronchus Dilatation (when infected), secondary infections of chronic respiratory infections, acute and chronic bronchitis, etc.

2. Urinary and reproductive tract infections. Such as gonococcal urethritis, cervicitis, pyelonephritis, cystitis, gonorrhea, etc.

3. Intra-abdominal infections (including cholecystitis, cholangitis, and peritonitis).

4. Scarlet fever, otitis media, paranasal sinusitis, etc.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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