Amphotericin B

Description

Amphotericin B Basic information

Product Name:	Amphotericin B
Synonyms:	FUNGIZONE;FUNGIZONE(R);ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE
CAS:	1397-89-3
MF:	C47H73NO17
MW:	924.08
EINECS:	215-742-2
Product Categories:	Antibiotics; Antibacterial; Antimycobacterial; ABELCET; APIs; Miscellaneous Natural Products; Intermediates & Fine Chemicals
Mol File:	1397-89-3.mol

Amphotericin Introduction

Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

Fungizone Chemical Structure

Amphotericin B

Amfotericina b Chemical Properties

Melting point	>170°C
alpha	D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl)
Boiling point	804.34°C (rough estimate)
density	1.34
refractive index	1.5280 (estimate)
storage temp.	2-8°C
solubility	sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20?#x00b0;C. Stable at 37?#x00b0;C for 3 days.
pka	pKa ～5.7(DMF/H2O) (Uncertain)
form	powder
color	yellow
Water Solubility	<0.1 g/100 mL at 21 ºC
Sensitive	Moisture & Light Sensitive
Merck	13,590
BRN	78342
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey	APKFDSVGJQXUKY-INPOYWNPSA-N
CAS DataBase Reference	1397-89-3(CAS DataBase Reference)
EPA Substance Registry System	Amphotericin B (1397-89-3)

Amfotericina b Usage And Synthesis

Chemical properties

It is pale yellow to orange needle crystal or powder. It is insoluble in water, ethanol, but soluble in acidic DMF, DMSO, and slightly soluble in DMF, acidic or alkaline water-containing lower alcohol. It is almost odorless, almost tasteless, and easy to be damaged by the light, heat and acid.

Uses

1. The product has strong inhibitory effect on various kinds of fungal infection, such as Cryptococcus neoformans, dermatitis budding yeast, histoplasma capsulatum, sporothrix schenkii, white candida, mucor sp and Coccidioides immitis. The goods are the primary choice of drugs for treating deep fungal disease.
2. It is a kind of polyene antifungal drugs. This drug binds to the sterol located on the fungal cell membranes sterol, disrupting the membrane permeability, causing the leakage of bacteria intracellular potassium ion, nucleotides, amino acids and therefore playing bactericidal effect by disrupting the normal metabolism.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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