7-Aminocephalosporanic Acid

Description

7-Aminocephalosporanic Acid, also named as 7beta-aminocephalosporanic acid, is the alpha,beta-unsaturated monocarboxylic acid that is the active nucleus for the synthesis of cephalosporins and intermediates. It derives from a cephalosporanic acid. It is a tautomer of a 7beta-aminocephalosporanic acid zwitterion.

Basic information

Product Name:	7-Aminocephalosporanic acid
Synonyms:	Cefazolin Sodium EP Impurity H (7-Aminocephalosporanic Acid); Cephalothin Impurity C(EP)（7-ACA; Aminocephalosporanic; Cefazolin EP Impurity H; 7-ACA Impurity; Ceftriaxone Impurity 18;7-AMinocephalosporanic acid 98%
CAS:	957-68-6
MF:	C10H12N2O5S
MW:	272.28
EINECS:	213-485-0
Product Categories:	Intermediates & Fine Chemicals; Pharmaceuticals; Organic acids; API intermediates; API

Chemical Structure

7-Aminocephalosporanic acid

Chemical Properties

Melting point	>300 °C (lit.)
alpha	94 º (c=0.5, KH2PO4, PH 7)
Boiling point	560.6±50.0 °C(Predicted)
density	1.4667 (rough estimate)
refractive index	1.5650 (estimate)
storage temp.	2-8°C
pka	2.59±0.50(Predicted)
form	Crystalline Powder
color	Off-white to beige
optical activity	[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH
Water Solubility	409.6mg/L(22.99 ºC)
Merck	14,434
BRN	622638
Stability:	Hygroscopic

Usage And Synthesis

Chemical Properties	Crystals.
Uses	Pharmaceutical intermediates. It is the starting material of many semi-synthetic cephalosporin. A variety of semi-synthetic cephalosporin industrial production is through fermentation to obtain cephalosporin C. Then obtain nucleus 7-ACA through chemical cleavage , and then the preparation is fininshed in chemically modified way .
Chemical Properties	Off-white to beige crystalline powder

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

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